effects of fluorodeoxyglucose magnetic nanoparticles on nci-h727 and sh-sy5y cancer cells

We present a report regarding the cytotoxic effects of iron-based magnetic nanoparticles conjugated with fluorodeoxyglucose (fdg-mnps) on the viability of nci-h727 and sh-sy5y cancer cells. mtt assays were performed to determine cell viability in treated cancer cells grown under standard 2d culture conditions. fdg-mnp concentrations of 0.075 mg/ml, 0.15 mg/ml, and 0.3 mg/ml decreased mean cell viability of nci-h727 cells to 92.5%, 82.9%, and 75% respectively. fdg-mnps was also shown to have a detrimental effect on the viability of sy5y cells: a decrease of 5.7%, 18.6%, and 36.4% was found for sy5y cells treated with 0.075 mg/ml, 0.15 mg/ml, and 0.3 mg/ml concentrations of fdg-mnps, respectively. when nci-h727 and sh-sy5y cancer cells were grown as 3d spheroids, morphology was visibly changed and the number of viable cells was decerased in spheroids treated with fdg-mnps compared with untreated spheroids. the results of our study demonstrated that fdg-mnp has toxic effects on nci-h7272 and sy5y cancer cells, and we conclude that conjugated fdg-mnps are promising in the development of clinical applications for the destruction of cancer cells.