an efficient one-pot, four-component synthesis of a series ofpyrazolo [3,4-b] pyridines in the presence of magnetic ldh as ananocatalyst

In this research study, one-pot, four-component reaction of 3-aryl-3-oxopropanenitriles, 1-aryl-3-methyl-1h-pyrazol-5 (4h) one, arylglyoxals andammonium acetate using green solvent systems and different catalysts underthe reflux conditions afforded a series of the corresponding 4-aroyl-3-methyl-1,6-diaryl-1h-pyrazolo [3,4-b] pyridine-5-carbonitrile derivatives.the best yields (70-85%) were obtained using the metal oxide silica basedmatalbifunctional ldh (layered double hydroxide) as a magnet nanocatalystin etoh/h2o (1:1) under the reflux conditions. this protocol provided mildreaction conditions, good yields, simple workup procedure, easy preparationof nanocatalyst and, products to structurally diverse bicyclic pyrazolo [3,4-b]pyridines, demonstrating biological and pharmacological activities.