new schiff base derivatives linked with inorganic bis-phosphonic acid moiety

Bis-phosphonic acid and bis-phosphonate derivatives are a diverse group of natural and synthetic compounds, they exhibit interesting physiological activities and are therefore considered as potential therapeutics in modern medicine. they have found applications as antibacterial, antiviral and as anti-osteoporosis drugs. the present work deals with the preparation of novel schiff base derivatives linked to inorganic bis-phosphonate groups by reacting the parent compound: bisphosphonic acid (4-aminophenyl) (hydroxyl) methylene (2) with a variety of aldehydes and ketones. the parent reactant and its condensation products (3a-3j) were identified by physical and spectroscopic techniques, namely; ft-ir, 1h-, 13c-, and 31p-nmr. the antibacterial activity of these derivatives were studied by disk diffusion method and found to possess high in vitro antimicrobial activity against gram-positive and gram-negative bacteria viz. staphylococcus aureus, bacillus anthraces, escherichia coli and acinetobacter species, referenced to azithromycin and levofloxacin.