new 𝑁-substituted maleimide homopolymers as drug carrier: synthesis and biological activity

In this work, new substituted drugs polymerized as new homogenous polymers with study their medicinal properties to extend the controlled drug. the first step includes preparation of compound n-(4-hydroxyphenyl) maleimide (d1) via reaction of maleic anhydride with 4-aminophenol. then compound (d1) was converted to maleimide phenol acetic acid ether (d2). compound (d2) was converted to its corresponding acyl chloride derivative which reacted with amino drugs (silver sulfadiazine, isoniazid, 4-aminoantpyrine) afforded monomers (d3, d4 and d5). homogeneous polymers (d6, d7, and d8) prepared via polymerization reaction of free radicals of the monomers (d3, d4, and d5) under nitrogen using benzoyl peroxide (bpo) as initiator. all these prepared monomers and polymers were characterized by ft-ir and 1h nmr, 13c nmr techniques and c.h.n.s were used to elementary analysis of the monomers. study of the drug release behavior in acidic and basic media as well as the swelling ratio were achieved. the antibacterial activity and physical properties of all monomers and polymers were studied.