synthesis¸ characterization and molecular modeling potential amide derivatives: evaluation of some biological and pharmaceutical activity

Some amide derivatives of drugs containing a carboxyl group (diclofenac¸ ketoprofen, oxaprozin, and naproxen) were prepared with one of the aniline derivatives. the effective method for preparing amides involves coupling amines with carboxylic acids utilizing dicyclohexylcarbodiimide (dcc) and 4-dimethylaminopyridine (dmap) under ordinary temperature conditions. the antioxidant activity was evaluated with the 2x08 protein. the results of molecular docking confirmed the biological activity of the prepared compounds and derivative 3 (n-(4-chlorophenyl)-2-((2,6 dichlorophenyl)amino)benzamide) showed high inhibitory activity according to the (phosphomolybdate assay) method. the other synthesized derivatives exhibited varying degrees of inhibition compared to ascorbic acid. additionally, the antibacterial (escherichia coli) and antifungal (candida albicans) activities of the prepared compounds were evaluated. the derivatives showed high to moderate activity compared to the standard references (cephalexin and fluconazole), with compound 2 showing significant activity against both bacteria and fungi. all the synthesized compounds were characterizedˮ using ft-ir, ¹h-nmr, 13c-nmr and molecular docking studies.