synthesis of new quinoline-2-carboxylic acid compounds and their antimicrobial activity investigation

In this study, synthesis of novel mannich bases, schiff bases, and heterocyclic compounds starting from quinoline-2-carboxylic acid has been achieved and their antimicrobial activities were studied. the first step involved the synthesis of compound e1 from reaction of 2-quinolinyl chloride with hydrazine. in the second step, compound e2 was prepared from the reaction of e1 with cs2 in an alkaline medium. the third step included the preparation of compounds e3-e7 from the reaction of e2 with different amines. in the fourth step, compound e8 was synthesized from the reaction of compound e2 with ethyl-2-chloroacetate in the presence of potassium carbonate. in the fifth step, compound e9 was prepared from the reaction of compound e8 with hydrazine in absolute ethanol. in the sixth step, compounds e10-e12 were prepared from a condensing reaction between compound e9 and different aromatic aldehydes. in the seventh step, compounds e13-e18 were prepared, respectively, from the reaction of thioglycolic acid and sodium azide with compounds e10-e12. finally, the prepared compounds were characterized by ft-ir and 1h-nmr spectroscopy, and their antimicrobial activities were studied.