transition metal complexes of new schiff base ligand derived from boron-based vanillin with study of some of their biological and medical applications

Synthesis of new schiff base ligand [(z)-4-(((1h-1,2,4-triazol-3-yl)imino)methyl)-2-methoxyphenyl dihydrogen borate] (l) by reaction of boron derivative of vanillin ( 4-formyl-2-methoxyphenyl dihydrogen borate) with 3-amino-1,2,4-triazole was carried on in a 1:1 mole ratio. in addition, the complexes of metal co(ii), ni(ii), and cu(ii) were characterized. each compound was characterized using spectroscopic techniques such as ft-ir, 1h-nmr, and uv-vis spectrometry. furthermore, the following analytical techniques were employed: thermal analysis (tg), atomic absorption spectroscopy (aas), elemental microanalysis (c.h.n), measurements of the melting point, chloride analysis, magnetic sensitivity testing, and molecular conductivity tests. all of the complexes exhibited non-electrolytic behavior and their indicated geometrical shapes were octahedral. all compounds exhibited paramagnetic magnetic characteristics. the synthesized compounds possessed a good efficiency as antimicrobial activity (anti-bacterial and anti-fungal) against escherichia coli (gram-negative), staphylococcus aureus (gram-positive), and candida albicans. the synthesized compounds were assessed as an in vitro anti-cancer agent against human thyroid carcinoma (ftci33), the result showed that the copper complex was more effective compared to ligand and its other complexes.