synthesis, characterizations, biological activity and molecular docking study of new azo schiff -bases

A new schiff base (5) was synthesized by reacting the hydrazide derivative (3) with p-aminoacetophenone in the presence of a few drops of h2so4 in ethanol as a solvent. following this preparation, the diazonium salt was prepared by reacting compound (6) with sodium nitrate in the presence of hcl at 0-5 °c and performing a coupling reaction. this reaction involved the prepared diazonium salt and some substituted phenols, leading to the formation of the corresponding azo-schiff bases 7(a–e). target compounds were identified using ft-ir, 1h-nmr and 13c-nmr. the second part of the current work includes the investigation of molecular docking and biological activities such as antimicrobial and antifungal effects.