a novel study in the determination of loratadine in pharmaceutical samples by precipitating with 3,5-dinitrosalicylic acid utilizing the nag_4sx3_3d analyzer at 0-180o in conjunction with the continuous flow injection analysis (cfia) technique

An innovative and effective method for continuous flow injection analysis (cfia) was developed and included in the nag_4sx3_3d analyzer. the primary objective of this approach was to quantify the concentration of loratadine. this study presents a methodology for the quantification of loratadine, an antihistaminic medication, in pharmaceutical formulations. the samples are analyzed using the nag_4sx3_3d analyzer, which is a device that combines optical, chemical, electronic, and detection capabilities. the analyzer operates by receiving a cumulative signal, eliminating the need for amplification. the total distance travelled is 760 mm in relation to the variable yz -mv during a period of time represented by t seconds (measured in mm). the selection was made based on the accurate computation of the energy transducer profile. the relative standard deviations for loratadine are 0.09% at a concentration of 5 m.m and 0.1% at a concentration of 8 m.m for n = 6. the limit of detection (lod) and limit of quantification were found to be 611.076 ng and 129 μg, respectively, using a stepwise dilution of the lowest concentration on the calibration curve with a sample size of n = 13. the linear range has a correlation coefficient (r) of 0.9989, indicating a strong positive relationship. additionally, the linearity of this range is measured at 99.79% (r2) and recovery is not less than 96.58%, suggesting a high degree of conformity to a linear model. a comparative analysis was conducted between the outcomes of the suggested methodology and the existing uv-spectrophotometric approach, specifically at a wavelength of 275nm, revealing similar findings.