caro’s acidsilica gel catalyzed regioselective ring opening of epoxides with indoles and imidazoles under solvent-free conditions

An efficient and facile procedure has been developed for the ring opening of epoxides with nitrogen heterocycles such as indole and imidazole in the presence of caro’s acidsilica gel (casio2) as catalyst in solventless system. the reactions were administered underneath solventfree conditions. the current methodology offers many benefits like good yields, easy procedure, simple workup and ecofriendly reaction condition. the catalyst is well ready, stable and economical underneath the reaction conditions.