effectiveness of cabergoline in comparison with control in women with fibroids uterus: a randomized clinical trial

Background: uterine fibroids are one of the most common benign tumors that cause abnormal bleeding and pain in women of reproductive age. one of the objectives of this study is to evaluate the effect of cabergoline drug on the size and volume of uterine bleeding as well as menopausal symptoms in women with uterine myomas.methods: this double-blind clinical trial was conducted among 80 women with fibroid myomas and abnormal uterine bleeding (aub). the participants were allocated to two groups after random allocation. group i received cabergoline, 1 tablet (0.5 mg/w) orally once a week for 3 months. group ii obtained a placebo tablet (0.5 mg/w), taken at the same time. results: 80 patients were included in the study (40 patients in the control group and 40 patients in the cabergoline treatment group). no statistically significant difference was observed between the two groups in terms of age, number of pregnancies, number of births, body mass index, uterine myoma characteristics, myoma type, myoma volume, and myoma number. a 37% decrease in myoma size was observed in the cabergoline recipients, as well as a 25% decrease in the placebo group, which is not statistically significant (p-value >0.05).conclusion: cabergoline drug reduces the volume of bleeding and the number of uterine myomas, but this reduction is not statistically significant and requires more studies in this field.