Impact of Birth and Hospitalization Factors in Retinopathy of Prematurity

Background: retinopathy of prematurity (rop) is a pathologic condition in the retina characterized by abnormal vasoproliferation. we aim to investigate the correlation of different birth- and hospitalizationrelated factors in the progression of rop. methods: this historical cohort study performed in the ophthalmology center of ayatollah rouhani hospital in babol (babol university of medical sciences, babol, iran), included 828 infants (gestational age <35 weeks and birth weight <2500 g). also, data were collected from the history of hospitalized premature infants. results: the lower gestational weight of infants has been observed in rop infants (1418.05±547.09 g) compared to non-rop infants (1917.31±486.01 g) (p<0.001). in addition, the average gestationalage of rop infants (30.28±2.34 weeks) was younger than non-rop infants (33.26±1.00 weeks) (p=0.042). increase in the duration of hospitalization increased 6% the chance of rop in infants (or=1.06; 95%ci: [1.05,1.08]) (p<0.001). furthermore, increase in the count of blood replacement decreased 29% the chance of complete remission of rop (or=0.71; 95%ci: [0.51,0.95]) (p=0.029). the blood group does not have an impact on rop development or remission. conclusion: more birth weight of premature infants is associated with less chance of rop incidence. moreover, the lower gestational age is related to more chances of rop.