Celiac Disease Seropositivity in Dilated Cardiomyopathy Patients and Correlation with Ejection Fraction

Background: recent evidence suggests a connection between celiac disease and dilated cardiomyopathy. herein, we serologically screened for celiac in dilated cardiomyopathy patients and investigated its correlation with ejection fraction. methods: we selected 123 cardiomyopathy patients. patients were screened for celiac, using anti-tissue transglutaminase (ata), antigliadin (aga), and anti-endomysial (ema) immunoglobulin type a (iga) antibodies. total iga levels were also measured. results: of 123 patients, 3 were ema positive (2.4%), 4 were aga positive (3.3%) and 5 were ata positive (4.1%). ema positive patients had significantly lower ef values compared to ema negative patients (35±5 vs. 46.52±9.21, p-value: 0.034). similar results were observed for aga (32.5±14.34 vs. 46.7±8.8, p-value: 0.002), but not for either ata positivity (40±10 vs. 46.5±9.21, p-value: 0.126) or iga deficiency (50±5 vs. 46.14±9.37, p-value: 0.480). no significant difference wasobserved in the age and gender of seropositive patients compared to seronegative. conclusion: we observed a higher prevalence of celiac seropositivity among dilated cardiomyopathy patients compared to the general population. ema and aga positive patients had significantly lower ejection fractions compared to their negative counterparts.