the possible association between circadian rhythm chronotypes and unhealthy metabolic phenotypes in overweight/ obese women

Background: circadian rhythm affects individual body function and health. although it can regulate many biological processes in the body such as hormone release and eating habits, little is known about the relationship between circadian rhythm and metabolic disorders. therefore, the purpose of the present research was to examine the association between circadian rhythm chronotypes (crc) and metabolic health status components, in patients with overweight and obesity.methods: a crosssectional study was conducted at the healthcare centres of tehran. patients with overweight and obesity (ow/ob) (n 374) aged 18 to 56 years were rectruited. all participants were assessed for metabolic health status components based on karelis criteria (hdl, ldl, tg, hscrp and homair). morningness eveningness questionnaire (meq) was used for chronotype categorizing. also, bioelectrical impedance analysis (bia) was applied to evaluate body composition. regression model in crude and adjusted model was used to assess the relation between crc and metabolic status.results: the differences in crc were not significant in terms of karelis criteria components except hscrp (p=0.02). results had shown that the trend of hscrp tends to decrease from eveningness chronotype to morningness chronotype and it significantly increased in crude model (p=0.007) and adjusted model (p=0.03). in addition, hscrp had decreased significantly in morningness chronotype in comparison with eveningness chronotype in crude model [or (95% ci): 0.28 (0.10 to 0.79), p=0.01].conclusion: this study indicated an association between hscrp and crc in women patients with overweight and obesity, which indicates that inflammation may have a relation to the crc and metabolic status.