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reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review
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نویسنده
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gerstl brigitte ,sullivan elizabeth ,vallejo marcus ,koch jana ,johnson maximilian ,wand handan ,webber kate ,ives angela ,anazodo antoinette
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منبع
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journal of cancer survivorship - 2019 - دوره : 13 - شماره : 2 - صفحه:269 -281
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چکیده
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Fertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family subsequent to treatment. the objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer. electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy. in total, 77 studies were included which reported on reproductive outcomes after treatment for cervical cancer, endometrial cancer, gestational trophoblastic disease, and ovarian cancer. the main treatments included vaginal or abdominal radical trachelectomy, progestin therapy, salpingo-oophorectomy, and chemotherapy. the mean age at diagnosis for the study population and at birth were 30.5 years and 30.3 years, respectively. there were 4749 pregnancies (42%) reported for the included studies, with a miscarriage rate of 15% and a medical termination rate of 5%. the live birth rate was 74% with a 10% preterm rate. patients should be offered timely discussions, information, and counseling regarding the impact of gynecological cancer treatment on a patient’s fertility. furthermore, fertility-sparing strategies and fertility preservation should be discussed prior to starting treatment.
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کلیدواژه
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gynecological neoplasms ,survivors ,pregnancy ,oncofertility ,systematic review
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آدرس
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university of new south wales, the kirby institute, department of biostatistics, australia. sydney children’s hospital, kids cancer centre, australia, university of technology sydney, australian centre for public health and population health research, faculty of health, australia, sydney children’s hospital, kids cancer centre, australia, technical university of munich, department of epidemiology, germany, royal sussex county hospital, brighton and sussex medical school, uk, university of new south wales, the kirby institute, department of biostatistics, australia, prince of wales hospital, nelune comprehensive cancer centre, australia. university of new south wales, prince of wales clinical school, australia, university of western australia, cancer and palliative care research and evaluation unit, australia, sydney children’s hospital, kids cancer centre, australia. prince of wales hospital, nelune comprehensive cancer centre, australia. university of new south wales, school of women’s and children’s health, australia
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Authors
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