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   cancer survivors who fully participate in the profiles registry have better health-related quality of life than those who drop out  
   
نویسنده ramsey imogen ,corsini nadia ,eckert marion ,rooij belle h. de ,mols floortje ,horevoorts nicole j. e. ,poll-franse lonneke v. van de
منبع journal of cancer survivorship - 2019 - دوره : 13 - شماره : 6 - صفحه:829 -839
چکیده    Attrition and subsequent missing data pose a challenge in longitudinal research in oncology. this study examined factors associated with attrition in the profiles registry, and its impact on observed health-related quality of life (hrqol) estimates. sociodemographic, clinical, and hrqol data were collected annually from a cohort of 2625 colorectal cancer survivors between 2010 and 2015. participant characteristics according to time of dropout were compared using analysis of variance and chi-square tests. predictors of attrition were examined in logistic regression analysis. multilevel linear mixed models were constructed to investigate associations between attrition and hrqol over time. participants who dropped out were more likely to be female (or = 1.23, ci = 1.02–1.47), older (or = 1.20, ci = 1.09–1.33), less educated (or = 1.64, ci = 1.30–2.11), and to have depressive symptoms (or = 1.84, ci = 1.39–2.44) than full responders, and less likely to have high socioeconomic status (or = 0.74, ci = 0.61–0.94). participants who dropped out earlier reported significantly worse hrqol, functioning, and psychosocial symptoms, which declined at a steeper rate over time, than full responders. cancer survivors’ hrqol be overestimated in longitudinal research due to attrition of the most unwell participants. cancer survivors with the poorest health are at risk of dropping out of profiles and possibly withdrawing from other activities. optimizing participation in profiles—a potential mechanism for providing information and access to support—is an avenue for keeping this group engaged.
کلیدواژه cancer ,dropout ,patient-reported outcomes ,quality of life ,survivorship ,bias ,attrition
آدرس university of south australia, rosemary bryant ao research centre, school of nursing and midwifery and unisa cancer research institute, australia. netherlands comprehensive cancer organization, the netherlands, university of south australia, rosemary bryant ao research centre, school of nursing and midwifery and unisa cancer research institute, australia, university of south australia, rosemary bryant ao research centre, school of nursing and midwifery and unisa cancer research institute, australia, netherlands comprehensive cancer organization, the netherlands. tilburg university, department of medical and clinical psychology, corps—center of research on psychology in somatic diseases, the netherlands, netherlands comprehensive cancer organization, the netherlands. tilburg university, department of medical and clinical psychology, corps—center of research on psychology in somatic diseases, the netherlands, netherlands comprehensive cancer organization, the netherlands. tilburg university, department of medical and clinical psychology, corps—center of research on psychology in somatic diseases, the netherlands, netherlands comprehensive cancer organization, the netherlands. tilburg university, department of medical and clinical psychology, corps—center of research on psychology in somatic diseases, the netherlands. the netherlands cancer institute, division of psychosocial research and epidemiology, the netherlands
 
     
   
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