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Long-term health effects among testicular cancer survivors
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نویسنده
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Hashibe Mia ,Abdelaziz Sarah ,Al-Temimi Mohammed ,Fraser Alison ,Boucher Kenneth M. ,Smith Ken ,Lee Yuan-chin Amy ,Rowe Kerry ,Rowley Braden ,Daurelle Micky ,Holton Avery E. ,VanDerslice James ,Richiardi Lorenzo ,Bishoff Jay ,Lowrance Will ,Stroup Antoinette
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منبع
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journal of cancer survivorship - 2016 - دوره : 10 - شماره : 6 - صفحه:1051 -1057
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چکیده
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Testicular cancer is diagnosed at a young age and survival rates are high; thus, the long-term effects of cancer treatment need to be assessed. our objectives are to estimate the incidence rates and determinants of late effects in testicular cancer survivors. we conducted a population-based cohort study of testicular cancer survivors, diagnosed 1991–2007, followed up for a median of 10 years. we identified 785 testicular cancer patients who survived ≥5 years and 3323 men free of cancer for the comparison group. multivariate cox regression analysis was used to compare the hazard ratio between the cases and the comparison group and for internal analysis among case patients. testicular cancer survivors experienced a 24 % increase in risk of long-term health effects >5 years after diagnosis. the overall incidence rate of late effects among testicular cancer survivors was 66.3 per 1000 person years. higher risks were observed among testicular cancer survivors for hypercholesterolemia, infertility, and orchitis. chemotherapy and retroperitoneal lymph node dissection appeared to increase the risk of late effects. being obese prior to cancer diagnosis appeared to be the strongest factor associated with late effects. testicular cancer survivors were more likely to develop chronic health conditions when compared to cancer-free men. while the late effects risk was increased among testicular cancer survivors, the incidence rates of late effects after cancer diagnosis was fairly low.
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کلیدواژه
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Testicular cancer ,Late effects ,Cardiovascular disease ,Obesity
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آدرس
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University of Utah School of Medicine, Division of Public Health, Department of Family and Preventive Medicine, USA, University of Utah School of Medicine, Division of Public Health, Department of Family and Preventive Medicine, USA, University of Utah School of Medicine, Division of Public Health, Department of Family and Preventive Medicine, USA, Huntsman Cancer Institute, USA, University of Utah School of Medicine, Division of Epidemiology, Department of Internal Medicine, USA, Huntsman Cancer Institute, USA, University of Utah School of Medicine, Division of Public Health, Department of Family and Preventive Medicine, USA, Medical Informatics, Intermountain Healthcare, USA, Medical Informatics, Intermountain Healthcare, USA, University of Utah Health Sciences Center, USA, University of Utah, Department of Communication, USA, University of Utah School of Medicine, Division of Public Health, Department of Family and Preventive Medicine, USA, University of Turin, Cancer Epidemiology Unit, Department of Medical Sciences, Italy, Intermountain Urological Institute, USA, University of Utah School of Medicine, Division of Urology, Department of Surgery, USA, University of Utah School of Medicine, Division of Epidemiology, Department of Internal Medicine, USA
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Authors
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