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   the significant association of the dupa and caga genes of helicobacter pylori with peptic ulcer  
نویسنده zaraatgar gohardani hamid reza ,moghanloo ehsan ,badameh parisa ,rezaei soheila ,babaei vahid ,teimourian shahram
منبع journal of human, environment and health promotion - 2018 - دوره : 4 - شماره : 4 - صفحه:159 -163
چکیده    background: helicobacter pylori play a significant etiological role in various digestive diseases. peptic ulcer is caused by h. pylori, which destroys the duodenum mucus and is often observed in the individuals consuming tobacco, spicy and heavy meals, alcohol, coffee, and tranquilizers. several studies have indicated that duodenal ulcer promoting genes dupa and caga are involved in h. pylori etiology. the present study aimed to evaluate the correlation between these genes and peptic ulcer. methods: in this study, 500 stomach biopsy samples were assessed based on the rapid urease test and polymerase chain reaction (pcr) for h. pylori infection, followed by histological and microscopic examinations. results: the dupa and caga genes were subjected to pcr. although dupa showed no significant correlation with peptic ulcer, the caga genotype had a significant association with peptic ulcer (p < 0.05). similar to the dupa gene, blood group was not observed to be correlated with h. pylori infection. conclusion: according to the results, there are significant correlations between tobacco use (p < 0.05), tranquilizer use (p < 0.05), and meteorism (p < 0.05) with peptic ulcer. in addition, the expression of the caga and dupa genes was investigated in patients with nonulcer dyspepsia and peptic ulcer.
کلیدواژه helicobacter pylori ,peptic ulcer ,real time technique ,dupa ,caga
آدرس islamic azad university, damghan branch, school of microbiology, department of basic sciences, ایران. pasture institute of iran, department of virology, ایران, kashan university of medical sciences, school of medicine, department of microbiology and immunology, ایران, islamic azad university, varamin branch, department of microbiology, ایران, national institute of genetic engineering and biotechnology, department of molecular genetics, ایران, iran university of medical sciences, department of medical genetics, ایران, pasture institute of iran, department of virology, ایران
پست الکترونیکی teimourian.sh@iums.ac.ir

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