synthesis, characterization, antioxidant, and antimicrobial evaluation of novel (e)-4-(substituted benzylideneamino)phenol derivatives featuring heteroaryl and aryloxy substituents

In the present study, four 4-aminophenol derivatives, (e)-4-(((5-bromothiophen-2-yl)methylene)amino)phenol, (e)-4-(((5-bromofuran-2-yl)methylene)amino)phenol, (e)-4-(((5-nitrofuran-2-yl) methylene) amino)phenol, and 4 (e)-4-((3-(benzyloxy)-4-methoxybenzylidene) amino)phenol, were synthesized and characterized by ft-ir,  1h-nmr, and  13c-nmr. the synthesized compounds were tested for antimicrobial (gram-positive and gram-negative bacteria) and antioxidant activities. compounds g2 and h2 showed moderate activity against staphylococcus aureus compared to the standard novobiocin. in contrast, compounds e2, f2, and h2 exhibited medium-range activity against pseudomonas aeruginosa, while only compound h2 showed medium-range activity against escherichia coli. the newly synthesized compounds showed significant antioxidant activity (72.5% ± 0.43), (67.4% ± 0.68), (77% ± 1.03), and (60% ± 0.73) compared to ascorbic acid (76% ± 0.30). the present study delineated the broad-spectrum antimicrobial and antioxidant activities of the synthesized compounds.