application of basic magnetic phase transfer nanocatalysts in the one-pot and multicomponent synthesis of poly-substituted aniline

Using a nano-phase-transfer catalyst (nptc) to facilitate diverse organic reactions offers a promising approach to achieve mild, synergistic, and multi-component synthesis of valuable compounds under heterogeneous conditions. this study describes the synthesis of 3,5-diaryl-2,6-dicyanoanilines through a tandem cyclocondensation reaction using commercially available reagents and fe3o4@sio2@pr-hmta (hexamethylenetetramine) as the nptc. the reaction takes place in water, a green solvent, and involves the condensation of acetophenone, malononitrile, and an aromatic aldehyde at room temperature. notably, this methodology represents the first green, one-pot process for synthesizing poly substituted aniline derivatives using magnetic phase transfer catalyst in water.