introduction of a new ionic liquid based on tropine for the acceleration of the synthesis of several hetero-aromatic compounds and investigation of its physicochemical property and antibacterial activity

In this work, we synthesized a new ionic liquid ([c8-tropine].cl) by combining tropine with 1-chlorooctane without the use of any solvent. prepared ionic liquid was characterized utilizing mass, tga, chn, fesem, nmr, and ft-ir analysis techniques. potential energy surfaces of different pathways and calculated energy barriers beside a few nmr chemical shifts were explored to determine the structure of the catalyst. according to the curtin-hammett principle, two different products can be obtained, named min2a and min2b, in a ratio of 0.26:1 which the structures of these products were determined by comparing the experimental and calculated nmr chemical shifts. the calculations were performed using the dft (b3lyp) computational method with 6-31+g(d,p) and 6-311g(d,p) basis sets. the antibacterial activity of the catalyst was evaluated against escherichia coli (gram-negative) and staphylococcus aureus (gram-positive) using the agar well diffusion method. after the identification of the synthesized ionic liquid, it was utilized as an efficient catalyst for the synthesis of pyrido[2,3-d]pyrimidines, 1,2,4-triazolo[4,3-a]pyrimidines, bis-2-amino-4h-pyrane and spiro-2-amino-4h-pyran-oxyindole derivatives. these methods stand out for their convenient and uncomplicated catalyst preparation, minimal catalyst usage, straightforward work-up procedures, quick reaction times, and the ability to achieve good to high product yields under environmentally friendly conditions. furthermore, the catalyst can be easily recovered and reused several times.