preparation and identification of new 1,4-bis (5,3-substituted-2,3-dihydro-1h-pyrazole-1-yl) buta-1,4-dione derivatives with their antibacterial effect evaluation

A new series of 5,3-substituted-2,3-dihydro-1h-pyrazole derivatives (p1-10) have been synthesized via a cyclization reaction of substituted chalcones with succinichydrazide. structures of the prepared compounds were identified by ft-ir, and some of them were characterized by nuclear magnetic resonance for proton 1h-nmr and nuclear magnetic resonance for carbon 13c-nmr. the heat of formation (hf) and steric energy (se) have been calculated using (mopac) and (mm2) methods, respectively, using (cs-chemoffice-version 6.0) program. additionally, the biological activity for final products has been evaluated against gram-positive (staphylococcus aureus and staphylococcus epidermidis) and negative bacteria (escherichia coli and pseudomonas aeruginosa).