synthesis, biological evaluations and molecular docking of novel pyrazolyl, dihydro-1h-inden-1-one derivatives

A series of novel pyrazol-4-yl- dihydro-1h-inden-1-one derivatives were synthesized by using greener catalyst ph 12.5 (bleaching earth clay bec) as an efficient catalytic and peg-400 as a green, recyclable solvent. all the synthesized compounds are characterized with 1hnmr, 13cnmr, ir and mass spectroscopy techniques. the synthesized molecules are subjected for the molecular docking study with 6kzv-a enzyme, the compounds iib (e)-2-((1-(4-bromophenyl)-3-phenyl-1h-pyrazol-4-yl)methylene)-2,3- dihydro-1h-inden-1-one, iic(e)-2-((3-phenyl-1-(p-tolyl)-1h-pyrazol-4- yl)methylene)-2,3-dihydro-1h-inden-1-one, iid (e)-2-((1-(4- methoxyphenyl)-3-phenyl-1h-pyrazol-4-yl)methylene)-2,3-dihydro-1hinden- 1-one and iie (e)-2-((1-(4- nitrophenyl)-3-phenyl-1h-pyrazol-4- yl)methylene)-2,3-dihydro-1h-inden-1-one shows the desired bonding interaction with 6kzv-a enzyme. the compounds further were evaluated for antimicrobial activities. amongst these synthesized compounds, the mentioned compounds show good to moderate antimicrobial activities.