synthesis, characterization and anti-corrosion activity of new triazole, thiadiazole and thiazole derivatives containing imidazo[1,2-a]pyrimidine moiety

In this research, several heterocyclic rings (triazole, thiadiazol, thiazol) containing imidazo (1,2-a) pyrimidine moiety have been prepared via a series of reactions. to do this, synthesis of 2-substituted imidazo (1,2-a) pyrimidine was performed by condensation of 2-aminopyrimidine with (4-bromo phenacyl bromide) or (4-phenyl phenacyl bromide). carbaldehyde group was prepared at position-3 of 2-substituted imidazo/pyrimidine rings by vilsmeier-haak reaction. thiosemicarbazon derivatives (schiff bases) were synthesized by condensation of 3-carbaldehyde derivatives with thiosemicarbazide. cyclization of thiosemicarbazone derivatives with ac2o, 4- bromophenacyl bromide and hcl afforded the corresponding thiadiazole(diacetyl) derivatives, 1,3-thiazole derivatives and 1,2,4-triazole derivatives respectively. structures of the new derivatives were confirmed via ft-ir spectroscopy, some of which were confirmed via 1h-nmr spectroscopy. three of these new derivatives were evaluated by their anti-corrosion activity.