Electrochemical Amplified Sensor With Mgo Nanoparticle and Ionic Liquid: A Powerful Strategy For Methyldopa Analysis

In this research, an amplified sensor based on paste electrode (pe) modified with mgo nanoparticle (mgo/nps) and 1-hexyl-3-methylimidazolium hexafluorophosphate (hmh) was designed and used for determination of methyldopa (md). the cp/mgo/nps/hmh showed good catalytic activity toward oxidation of md and improved drug current about 3.58 times. in addition, cp/mgo/nps/hmh showed a diffusion process and ph dependence behavior for electro-oxidation of md in aqueous solution. however, differential pulse voltammogram of cp/mgo/nps/hmh showed a linear dynamic range to sensing of md in concentration range 1.0 nm – 400 µm with detection limit 0.5 nm. the recovery range 98.25% - 102.5% was obtained for sensing of md in real samples using cp/mgo/nps/hmh.