n1,n1,n2,n2-tetramethylethylenediaminium-n1,n2-disulfonic acid trifluoroacetate as highly effectual and dual-functional catalyst for the reaction of β-ketoesters with aryl aldehydes and urea/thiourea

In this research, the one-pot multi-component reaction of β-ketoesters with aryl aldehydes and urea/thiourea has been performed using a dual-functional ionic liquid-catalyst namely n1,n1,n2,n2-tetramethylethylenediaminium-n1,n2-disulfonic acid trifluoroacetate ([tmedsa][tfa]2) in solvent-free conditions. by reason of dual-functionality of the catalyst (possessing acidic and basic sites), and also having two numbers of each site, it was highly effectual and general catalyst, and afforded the products {3,4-dihydropyrimidin-2-(1h)-ones and 3,4-dihydropyrimidin-2-(1h)-thiones} in short times with excellent yields. moreover, a plausible mechanism based on dual-functionality of the catalyst has been proposed.