Efficient Synthesis of Β-Lactam-Containing Α-Aminophosphonates Using Fumaric Acid As Mild Catalystɸ
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نویسنده
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Vangala Vijaya Bhaskar ,Pati Hari Narayan
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منبع
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Chemical Methodologies - 2018 - دوره : 2 - شماره : 4 - صفحه:333 -340
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چکیده
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A short and efficient protocol for the synthesis of novel α- aminophosphonate esters containing β-lactam moiety is described. inexpensive and mild acid catalyst such as fumaric acid was used for the synthesis of α-aminophosphonate esters by reacting n-(4- methoxyphenyl)-2-(substituted) propiolactam-3-carbaldehyde with amine and triethylphosphite in acetonitrile under reflux conditions. α-aminophosphonate esters containing β-lactam hybrids were obtained in moderate to good yield and purity.
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کلیدواژه
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Fumaric Acid ,Α-Aminophosphonate Ester ,Β-Lactam
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آدرس
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پست الکترونیکی
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hnpati@gmail.com
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