green extraction and 𝘐𝘯 𝘝𝘪𝘷𝘰 screening of 𝘔𝘺𝘳𝘪𝘤𝘢 𝘕𝘢𝘨𝘪 bark for antidepressant, antidiabetic, and analgesic potentials

The myricaceae family’s subtropical shrub known as myrica nagi hook (syn. myrica esculenta buch. ham) is frequently referred to as boxberry. it is an average to large, dioecious, evergreen tree with a trunk circumference of 92.5 cm, and light brown to black bark. several chemical compounds in m. nagi have been shown to be potent antioxidants, and m. nagi has been linked to various pharmacological activities. this study analyzed the antidepressant, antidiabetic, and analgesic properties of myrica nagi (m. nagi) ethanol bark extract in swiss albino mice. the extraction was performed using the maceration technique. the forced swimming test (fst), tail suspension test (tst), and alloxan-induced diabetic model were used alongside analgesic assays, such as the hot plate and acetic acid-induced writhing test. the proposed activities were evaluated using these procedures. antidepressant action was observed in the fst and tst at a higher dose (400 mg/kg). significant antidiabetic action was observed in alloxan-induced diabetic mice when the bark extract was administered at 200, 300, or 400 mg/kg. the ethanol extract of the bark at three concentrations (200, 300, and 400 mg/kg) showed substantial analgesic effects in both the hot plate and acetic acid-induced tests. according to our findings, m. nagi bark extract has antidepressant, antidiabetic, and analgesic properties. however, further studies are needed to isolate bioactive ingredients and better understand the molecular mechanisms and modes of action of these pharmacological benefits.