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   synthesis of novel thiazole based 1,2,3-triazole derivatives as inhibitors of glioblastoma cancer cells  
   
نویسنده kuna sateesh ,kandula kotaiah ,myakala nagaraju ,thumma vishnu ,bhavani anagani kanaka durga
منبع asian journal of green chemistry - 2025 - دوره : 9 - شماره : 2 - صفحه:193 -207
چکیده    A library of thiazole – 1,2,3-triazole hybrids through the conventional 1,3-dipolar cycloaddition reaction of ethyl 2-(3-formyl-4-(prop-2-yn-1-yloxy) phenyl)-4-methylthiazole-5-carboxylate based alkyne via click reaction. spectral data, such as ir, 1h-nmr, 13c-nmr, and mass, were used to characterize the molecules structures. synthesized compounds were screened for in vitro anticancer effects on human glioblastoma cell lines. some compounds displayed potent activity with ic50 values of 10.67±0.94 µm, 4.72±3.92 µm, and 3.20±0.32 µm, in contrast to reference drug temozolomide. computational study against thymidylate synthase demonstrated favourable docking scores and binding interactions like h-bond, π-π stacked, and π-sulfur.
کلیدواژه cytotoxicity ,glioblastoma ,molecular docking ,thiazole ,triazole
آدرس osmania university, university college of science, department of chemistry, india. geethanjali college of engineering and technology, india, osmania university, university college of science, department of chemistry, india, osmania university, university college of science, department of chemistry, india, matrusri engineering college, department of sciences and humanities, india, osmania university, university college of science, department of chemistry, india
پست الکترونیکی durgabhavani237@gmail.com
 
     
   
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