|
|
|
|
synthesis, molecular docking, and biological evaluation of some new naphthalene-chalcone derivatives as potential anticancer agent on mcf-7 cell line by mtt assay
|
|
|
|
|
|
|
|
نویسنده
|
more vijaykumar s. ,panchgalle sharad p. ,gayake ranjit a. ,jagrut vasant b. ,kodape manisha m. ,birhade deekshaputra r. ,lokhande mahendra n.
|
|
منبع
|
asian journal of green chemistry - 2024 - دوره : 8 - شماره : 3 - صفحه:234 -246
|
|
چکیده
|
Naphthalene chalcones (3a-i) with excellent yields were achieved through the use of aromatic ketones, 1-naphthaldehyde, and aqueous naoh in the synthesis process. the synthesized chalcones were bio-evaluated as potential tubulin polymerization inhibitors for the treatment of breast cancer. the antiproliferative potential of each synthesized compound against the mcf-7 cell line was assessed. the majority of the compounds showed strong antiproliferative properties. with an ic50 value of 222.72 µg/ml, compound 3f exhibited the most antiproliferative activity among them, surpassing that of 5fu (ic50, 51.47 µg/ml).
|
|
کلیدواژه
|
naphthalene-chalcone ,breast cancer ,antitumor activity ,mcf-7 cell line
|
|
آدرس
|
kai. rasika mahavidyalaya deoni, department of chemistry, india, k. m. c. college khopoli, department of chemistry, india, swami vivekanand sr. college mantha, department of chemistry, india, swami vivekanand sr. college mantha, department of chemistry, india, sant gadge baba amravati university, department of chemistry, india, shri vyankatesh arts, commerce and science college deulgaon raja, india, aavvaiyar government college for women karaikal, department of chemistry, india
|
|
پست الکترونیکی
|
mnlok@dhtepdy.edu.in
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|