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   solvent-free mechanochemical green synthesis of schiff bases of tranexamic acid and study of their urease inhibitory and antioxidant activities  
   
نویسنده zulfiqar abid ,ahmed dildar
منبع asian journal of green chemistry - 2022 - دوره : 6 - شماره : 1 - صفحه:40 -47
چکیده    Three schiff bases of tranexamic acid were successfully synthesized by a mechanochemical green method, which is 4-{(5-bromo-2- hydroxybenzylidene)amino]methyl}cyclohexanecarboxylic acid (sb1), 4-{(2-hydroxybenzylidene)amino]methyl}cyclohexanecarboxylic acid (sb2), and 4-{(4-nitrobenzylidene)amino]methyl}cyclohexanecarboxylic acid (sb3) in good yield. their structures were confirmed based on spectroscopic data. the bases displayed considerable urease inhibitory activity with ic50 (μg/ml) 33.41, 40.64, 26.18, and 11.14 for sb1, sb2, sb3, and standard thiourea, respectively. they revealed weak antiradical activity in dpph assay with ec50 (μg/ml) 1138, 1239, and 24248 for sb1, sb2, and sb3, respectively. in conclusion, grinding is an efficient and environmentally friendly method for synthesizing these bases, which may provide potential candidates for new medicines.
کلیدواژه tranexamic acid derivatives ,bioactivities ,green chemistry ,grinding method
آدرس forman christian college, department of chemistry, pakistan. inm-leibniz institute for new materials, germany, forman christian college, department of chemistry, pakistan
پست الکترونیکی dildarahmed@fccollege.edu.pk
 
     
   
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