Nano Particles Graphene Oxid: A Green and Effective Catalyst For Synthesis of Pyrazoles

In this work, a green and effective method for the synthesis of pyrazole derivatives by the reaction of a pot of various 1,3-dicarbonyl compounds with hydrazine is proposed using graphene oxide nanoparticles as the lewis base catalyst. advantages this methods are high yields, perform quick reactions, easy customization, and short-term reaction. the catalyst was recycled several times. the recycled catalyst was reused without any apparent performance drop in subsequent reactions. this process provided not only self-condensation but also cross-condensation by using the hydra-friendly nuclear reaction of hydrazines and high-efficiency, multisubstituted pyrazoles were formed under good and easy conditions.