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organocatalytic enantioselective onepot synthesis of β-aminoketones via mannich reaction
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نویسنده
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menkudle madhavi s. ,chakrawar avinash v. ,kulkarni prashant m. ,jadhav wamanrao n. ,bhusare sudhakar r.
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منبع
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asian journal of green chemistry - 2020 - دوره : 4 - شماره : 3 - صفحه:249 -255
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چکیده
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An effective protocol for the asymmetric synthesis of β-amino carbonylcompounds using pyrrolidine based organocatalyst has been developed viaone-pot three-component mannich reaction. the organocatalyst (s)-n-(2,4-dinitrophenyl) pyrrolidine-2-carboxamide 3b confirmed to be the superiororganocatalyst in solvent acetonitrile to obtain corresponding products in upto 89% yield and with excellent ee (90%). this organocatalytic reactionreveals productive result with a range of other aldehydes. aromaticaldehydes having electron withdrawing substituent show the best results.excellent yields, high enantioselectivity, mild reaction condition, and simpleexperimental work-up procedure are some of the advantages of this method.© 2020 by spc (sami publishing company), asian journal of greenchemistry, reproduction is permitted for noncommercial purposes.
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کلیدواژه
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mannich reactionorganocatalystβ-amino carbonyl compoundsenantioselectivitymulticomponent reaction
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آدرس
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dnyanopasak college, department of chemistry, india, dnyanopasak college, department of chemistry, india, dnyanopasak college, department of chemistry, india, dnyanopasak college, department of chemistry, india, dnyanopasak college, department of chemistry, india
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پست الکترونیکی
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bhusare71@yahoo.com
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Authors
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