Organocatalytic Enantioselective Onepot Synthesis of Β-Aminoketones Via Mannich Reaction

An effective protocol for the asymmetric synthesis of β-amino carbonylcompounds using pyrrolidine based organocatalyst has been developed viaone-pot three-component mannich reaction. the organocatalyst (s)-n-(2,4-dinitrophenyl) pyrrolidine-2-carboxamide 3b confirmed to be the superiororganocatalyst in solvent acetonitrile to obtain corresponding products in upto 89% yield and with excellent ee (90%). this organocatalytic reactionreveals productive result with a range of other aldehydes. aromaticaldehydes having electron withdrawing substituent show the best results.excellent yields, high enantioselectivity, mild reaction condition, and simpleexperimental work-up procedure are some of the advantages of this method.© 2020 by spc (sami publishing company), asian journal of greenchemistry, reproduction is permitted for noncommercial purposes.