|
|
Imidazole Mediated Synthesis of Spirooxindoles in Water Using Isatin As A Privileged Scaffold
|
|
|
|
|
نویسنده
|
Khan Md. Nasim ,Parmar Digvijaysinh K. ,Bhatt Hardik B.
|
منبع
|
Asian Journal Of Green Chemistry - 2019 - دوره : 3 - شماره : 4 - صفحه:470 -482
|
|
|
چکیده
|
This work discusses the synthesis of complex small molecules spirooxindoles using imidazole as an efficient organocatalyst. the three components coupling reactions of isatin, malononitrile, and enolizable 4-hydroxycoumarin were performed in water as a green solvent. the reaction was done with imidazole, an amphoteric organocatalyst, to construct the spiro-molecules with high yields. the significant features of this protocol are neutral reaction condition, availability, low cost, metal free, strong acid/base free, and reusable reaction medium with no column chromatography separation. this methodology is useful for the easy access of structurally complex, highly functionalized spirooxindole molecules with the important medicinal chemistry applications.
|
کلیدواژه
|
Imidazole ,Spirooxindole ,Water ,Multicomponent Reaction ,Organocatalysis
|
آدرس
|
Iqra Pharmaceuticals, India, Diu College, India, Om College Of Science, India
|
پست الکترونیکی
|
bhatthardik_msc@yahoo.com
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|