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   stability indicating assay method for simultaneous estimation of nebivolol and valsartan in pharmaceutical dosage form by rp-hplc  
   
نویسنده vyas amit ,nathwani grishma ,patel ajay ,patel ashok ,patel nilesh ,makvana nirav
منبع asian journal of green chemistry - 2018 - دوره : 2 - شماره : 3 - صفحه:227 -245
چکیده    a simple, rapid, precise, and accurate isocratic reversed-phase stability indicating hplc method was developed and validated for simultaneous determination of the nebivolol and valsartan in the tablet dosage form. the effective chromatographic separation was achieved by a ymc pack pro octadecyl silane (150×4.6 mm, 3 μm) column using a mobile phase composed of methanol: acetonitrile: 0.05 m potassium dihydrogen phosphate buffer (ph=3.0 with 10% ortho phosphoric acid after addition of 0.2% triethylamine) (30:30:40, v/v/v) at a flow rate of 1 ml/min and uv detection at 282 nm. drugs were subjected to the acid, base, oxidation, heat, and photolysis to apply the stress. linearity ranges were 5–30 μg/ml (r2= 0.9989) for nebivolol and 80-480 μg/ml (r2=0.9991) for valsartan. limit of detection was 0.38 μg/ml and 1.08 μg/ml for nebivolol and valsartan, respectively. the limit of quantification for the nebivolol and valsartan was 1.15 μg/ml and 3.27 μg/ml, respectively.
کلیدواژه nebivolol ,valsartan ,rp-hplc ,stability indicating ,validation
آدرس b.k. mody government pharmacy college, india, b.k. mody government pharmacy college, india, b.k. mody government pharmacy college, india, b.k. mody government pharmacy college, india, b.k. mody government pharmacy college, india, b.k. mody government pharmacy college, india
 
 

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