One-Pot, Four Component Synthesis of Pyrazolo[4′,3′:5,6]Pyrido[2,3-D]Pyrimidines Derivatives

A green approach to synthesis of the polyfunctionalized pyrazole [4′,3′:5,6]pyrido[2,3-d] pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of tea (triethylamine) as a catalyst in water under the reflux conditions. this protocol provided mild reaction conditions, short reaction times, high yields, low cost, easy isolation of products and possible biological, and pharmaceutical activities.