comparison of ketamine and dexmedetomidine in reducing complications after laparoscopic cholecystectomy surgery

Background: today, the use of less invasive methods for surgery in the hospital is increasing due to less injuries and complications and faster recovery. one of the most important issues after surgery is to find a drug that can provide the longest period of pain relief and sedation for the patient with minimal side effects. this study was conducted with the aim of comparing ketamine and dexmedetomidine in reducing complications after laparoscopic cholecystectomy surgery. methods: this study was a double-blind randomized clinical trial. 90 patients were evaluated after laparoscopic cholecystectomy surgery. patients were randomly divided into three control groups, intervention group with ketamine and intervention group with dexmedetomidine. the level of sedation, pain, shivering and nausea and vomiting of the patients after the operation were evaluated.result: frequency of patient sedation at the time of entering recovery was significantly different between ketamine, dexmedetomidine and control groups (p=0.006). the comparison of pain in ketamine, dexmedetomidine and control groups showed that the average pain in 15 minutes later, 30 minutes later, 45 minutes later, 60 minutes later, at the time of entering recovery and leaving recovery in the dexmedetomidine group (0%), it was significantly lower than the ketamine and control groups (p<0.001). comparison of shivering in ketamine, dexmedetomidine and control groups showed that the frequency of shivering at the time of entering recovery in dexmedetomidine group (0%) was significantly lower than ketamine and control groups (p<0.001). frequency of nausea at the time of entering recovery in dexmedetomidine group (0%) was significantly higher than control and ketamine groups (p<0.001). conclusion: based on the results of the present study, the use of dexmedetomidine in laparoscopic cholecystectomy surgery causes relaxation, reduces pain and shivering after the operation compared to ketamine. therefore, this drug can be used as an anesthetic aid in surgery.