Neurological Disorders due to Recurrent Hypoglycemia

The most important material for the brain tissues is glucose .the brain utilizes around (25%) of the body's glucose, and it's metabolism thought to be primarily by astrocytes through non-insulin dependent (glut-1) transporter and insulin dependent (glut-4) transporter, but the brain contains very limited stores of glycogen, and therefore it can't regulate it's function for long time without glucose.so neuronal damage can lead to multiple neurological manifestations as a result of hypoglycemia acutely; stroke like symptoms, movement disorders (tremor, ataxia, difficulty of walking), seizures, coma and death; chronically and repetitive leads to cognitive impairment. which means clinical picture appears according to the area of neuronal damage.