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An early Bayesian Network Meta-analysis of Coronavirus Diseases 2019 (COVID-19) clinical trials
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نویسنده
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javdani farshid ,abdi mohammad hashem ,abiri samaneh ,haghbeen marzieh ,rastgarian ahmad ,damshenas mohammad hasan ,keshavarz pouyan ,akbarnejad mohammad amin ,hatami naser ,ahmadi reza ,habibzadeh reza ,john mehramiz neema ,foroughian mahdi ,kalani navid
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منبع
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international journal of medical investigation - 2020 - دوره : 9 - شماره : 3 - صفحه:1 -4
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چکیده
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In this paper, we conducted a bayesian network meta-analysis of the latest covid-19 clinical trialsincluding 5 studies on 591 patients receiving 4 different agents of arbidol, favipiravir, lopinavirritonavir, and hydroxychloroquine and standard treatment protocol. we ranked the best agent based on patient improvement using markov-monte-carlo-chain. hydroxychloroquine showed the best efficiency following the favipiravir, arbidol, lopinavir-ritonavir, and standard regimen in the first week of treatment. in the second week, with excluding hydroxychloroquine arm (as some reporting studies hadn't addressed its efficacy in the second week), favipiravir was the best treatment following by lopinavir-ritonavir, standard care, and arbidol. as we saw a huge change in the ranking of the drugs by evaluating outcomes in the second week of treatment, we think that covid-19 randomized clinical trials should be performed based on a standard study protocol worldwide, that could help policy makers to make a decision on the treatment protocol.
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کلیدواژه
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Network Meta-analysis ,Favipiravir ,SARS-CoV-2 ,COVID-19 ,lopinavir-ritonavir
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آدرس
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jahrom university of medical sciences, student research committee, Iran, jahrom university of medical sciences, department of nursing, Iran, jahrom university of medical sciences, research center for social determinants of health, Iran, jahrom university of medical sciences, research center for social determinants of health, iran, jahrom university of medical sciences, anesthesiology, critical care and pain management research center, Iran, jahrom university of medical sciences, anesthesiology, critical care and pain management research center, Iran, jahrom university of medical sciences, student research committee, Iran, jahrom university of medical sciences, student research committee, Iran, jahrom university of medical sciences, student research committee, Iran, mashhad university of medical sciences, faculty of medicine, department of emergency medicine, Iran, mashhad university of medical sciences, faculty of medicine, department of emergency medicine, Mashhad, banner university, medical center, department of psychiatry neurology, USA, mashhad university of medical sciences, faculty of medicine, department of emergency medicine, Iran, jahrom university of medical sciences, research center for social determinants of health, iran
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Authors
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