does gabapentin decrease post-mastectomy acute and chronic pain? a systematic review of clinical trials

Introduction: mastectomy is associated with moderate to severe pain. researchers are recentlyexploring new modalities and drugs to avoid numerous side effects associated with prescribednarcotics. for treatment, gabapentin is a widely used medication, but there is no comprehensivereport on the post-mastectomy effects of this medication. thus, this study aims to evaluate theeffects of gabapentin on managing acute pain after surgery.methods: this was a systematic review (prisma checklist) study in which clinical trial articlespublished between 2000-2020 using the cochrane checklist in pubmed, ovid, medline, scopus,web of science with breast keywords cancer, gabapentin, postoperative pain, mastectomy, breastsurgery, postoperative analgesia, eras, multimodal therapy were sought to evaluate the effect ofgabapentin on post-mastectomy pain.results: in the initial search, 288 articles were found. twenty-one articles were ultimately selectedby repeated trading off, including reviewing texts and abstracts, outcomes, results, and the generalconclusion, and included in this meta-analysis; the results of most studies have shown thatgabaanthin can lead to acute and chronic pain decrease post-mastectomy. gabapantin also reducedthe need for drugs to control pain.conclusion: dispensing gabapentin as a single treatment or in combination with other therapiesmeaningfully alleviates pain and diminishes drug use after breast surgery.