Excess Iron Ion Reduction in A Thalassemia Model Using Silver Nanoparticles Modified By the Tannin Fraction of Myrtus Communis Extact

Objective(s): nowadays, iron ions intoxication is the center of attention of interest in the management and treatment of thalassemia and different sorts of anemia associated with regular blood transfusions. due to the major side effects of current drugs, they should be replaced with safer alternatives. thus, in this study, functionalized hybrid silver nanoparticles, as an emerging perspective, were investigated for absorbing excess iron ions and their removal in an animal thalassemia model. methods: the silver nanoparticles were greensynthesized using the myrtus communis leaf methanolic extact (mcagnps). the produced hybrid nanosorbents based on hydrolyzable tannin matrix loaded with silver nanoparticles were delivered for trying out in vivo iron chelation in thalassemia model mice in which ironoverload was imposed. mcagnps and desferral were injected intraperitoneally four times a week for one month in mice with excess iron load. the total iron and fe3+ content of serum was evaluated with the aid of plasmaatomic spectrometry microscopy and a fe3+ ion measurement kit, respectively. also, liver enzyme levels were evaluated by an autoanalyzer. also, hepatic enzyme levels were appraised by using an autoanalyzer based the corresponding kits. morphological transformations of the liver tissue were investigated by way of prussian blue staining. results: the mice treated with the mcagnps demonstrated a significant reduction in serum iron content when compared with the ironoverload mice. mcagnps revealed satisfying effectiveness to chelate excess iron in mice. conclusions: this method could be considered as a competitive option for lowering the level of excess iron in vivo.