micrornas in t-cell acute lymphoblastic leukemia: roles and contributions to treatment response

T-cell acute lymphoblastic leukemia (t-all) is an aggressive hematologic malignancy induced by the proliferation of immature t-cell precursors. even with the development of multi-agent chemotherapy, treatment failure, and relapse remain the most important challenges because of drug resistance. mirnas are a class of small non-coding rnas that modulate the expression of target mrnas at the post-transcription level. they play significant roles in many biological processes, including tumorigenesis, differentiation, and apoptosis. recent research has underlined the contribution of specific mirnas to the pathogenesis of t-all and drug resistance. in the present review, the therapeutic potential of mirna modulation in t-all disease will be discussed according to their role in disease biology, mechanisms of resistance, and possible strategies for clinical application.