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effects of topical application of royal jelly on second-degree burn wound healing in male rats
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نویسنده
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mahdian zeinab ,amiri fereshteh ,mohammadi zohreh ,farzadinia parviz ,safizadeh fahimeh ,zare zahra ,rahimi rahimeh ,dehghani zahra ,mohammadi tahroodi fariba
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منبع
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international journal of medical laboratory - 2020 - دوره : 7 - شماره : 4 - صفحه:289 -299
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چکیده
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Background and aims: burn injury remain as a major medical problem throughout the world. this injury is accompanied with inflammatory and wound healing responses. since royal jelly (rj) has anti-inflammatory and wound healing activity therefore, the aim of this study was to evaluate the repairing effects of rj on skin burn- damage. materials and methods: in an experimental study, 40 male wistar rats (8 weeks old) were engaged. the animals were divided into five equal groups. group 1 was considered healthy control. group 2 (positive control) was treated topically with silver sulfadiazine cream, group 3 received eucerin as negative control, and group 4, 5 treated with rj (10 and 30%). sampling was performed after observing the second-degree burns on the first, seventh and fourteenth days. then after 28 days, rats were sacrificed and their skin tissues were used for morphological and morphometric assessments. results: the results of this study showed that the amount and arrangement of collagen type 1 protein was higher in the rj treatment groups versus control group. reconstruction and thickening of the epithelium in rj treated groups confirmed therapeutic effects of rj. in addition, rj increased angiogenesis compared to the control group. the wound's surface area was reduced in the rj treatment groups compared to the control group. in addition, fibroblast cell proliferation was increased in the groups receiving rj versus control. conclusions: it could be concluded that, rj induce wound healing effects and might be considered as potential treatment option to improve the burn wound healing.
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کلیدواژه
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burns ,inflammation ,royal jelly ,wound healing
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آدرس
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babol university of medical sciences, faculty of medicine, department of biochemistry, iran, islamic azad university, tehran science and reserch branch, department of biology, iran, islamic azad university, kerman branch, department of microbiology, iran, bushehr university of medical sciences, faculty of medicine, department of biology and anatomical sciences, iran, iranian social security organization, iran, farhangian university, department of biology, iran, bushehr university of medical sciences, faculty of medicine, department of biochemistry, iran, bushehr university of medical science, department of pathology, iran, kerman university of medical sciences, department of clinical biochemistry, afzalipour school of medicine, iran
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پست الکترونیکی
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faribamt93@yahoo.com
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جهش های ژن DNMT3A در لوسمی میلوئیدی حاد و لوسمی لنفوئیدی حاد
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Authors
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مهدیان زینب ,امیری فرشته ,محمدی زهره ,فرزادی نیا پرویز ,صفی زاده فهیمه ,زارع زهرا ,رحیمی رحیمه ,دهقانی زهرا ,محمدی تهرودی فریبا
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Abstract
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زمینه و اهداف:DNA متیل ترانسفراز3A برای تنظیم بیان ژن ضروری است و جهش ها در ژن DNMT3A در بسیاری از سرطان های خون گزارش شده است.جهش های DNMT3A در طول پیشرفت سرطان موجود است و سبب پیش آگهی منفی در بسیاری از سرطان ها می شود.بنابراین،این ژن می تواند هدفی برای درمان های جدید باشد.این مطالعه با هدف بررسی توزیع جهش های DNMT3A در بیماران لوسمی حاد ایرانی انجام شد.مواد و روش ها:در این مطالعه نمونه های 45 بیمار لوسمی حاد de novo ، شامل 23 بیمار AML و 22 بیمار ALL از فروردین 1396 تا اسفند 1396 جهت شیوع جهش های DNMT3A با PCR و سکانس مستقیم بررسی شد.نتایج:در کل 2(9.1%) مورد AML و یک(4.34%) مورد ALL دارای جهش R882H بودند .22.7% و 21.7% بیماران AML وALL به ترتیب دارای پلی مورفیسم rs368516543 بودند.جهش های DNMT3A بطور قابل توجهی با سن بالاتر در بیماران AML مرتبط بود.نتیجه گیری:این یافته ها پیشنهاد می کند که جهش های DNMT3A احتمالا بیومارکری جدید در بررسی اولیه و درمان لوسمی حاد است،هرچند مطالعات بیشتر نیاز است.
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Keywords
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