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determination of fasting blood sugar and cholesterol levels in gotvand city
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نویسنده
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roshanmehr hoshang ,rostami morad ,seyedtabib maryam ,kamyari naser
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منبع
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international journal of medical laboratory - 2020 - دوره : 7 - شماره : 4 - صفحه:267 -279
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چکیده
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Background and aims: due to the high prevalence of carbohydrate and lipid metabolism disorders worldwide and in iran and as recommended by the international diabetes federation, about more investment in diabetes research in iran, it is decided to perform of this study in the urban and rural area of gotvad city in the khuzestan province of iran. materials and methods: in this cross-sectional study, among 31822 eligible people, 4138 people aged 29 years or more participated between november 2017 and march 2018. samples were obtained from patients, and after centrifugation and separation of serum, fasting blood sugar (fbs) and total cholesterol were measured employing the glucose and cholesterol assay kit of pars azmun company. since fbs and cholesterol statuses are ordinal, an ordinal logistic regression proportional odds model was used to identify the risk factors of responses if the proportional odds assumption satisfies. univariate analysis was performed with independent t-test and anova with a tukey posthoc. results: two models were determined, and except the area in predicting cholesterol status; all other covariates, including age, fbs value, cholesterol value, sex, and area in predicting fbs, were the significant predictors of cholesterol and fbs levels. conclusions: although there where a high prevalence of fbs and cholesterol level disturbances, from 24.9% and 25.9% of the population with disturbances in serum cholesterol and glucose levels, respectively, nearly 80% and 25.9% of them are in the borderline high group and impaired fasting glucose states, respectively which can return them to a healthy state with appropriate and prompt interventions.
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کلیدواژه
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cholesterol ,diabetes ,fasting blood sugar ,impaired fasting glucose
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آدرس
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dezful university of medical sciences, department of biochemistry, iran, ahvaz jundishapur university of medical sciences, department of biochemistry, iran, ahvaz jundishapur university of medical sciences, school of public health, department of biostatistics & epidemiology, iran, hamadan university of medical sciences, school of public health, student research committee, department of biostatistics, iran
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جهش های ژن DNMT3A در لوسمی میلوئیدی حاد و لوسمی لنفوئیدی حاد
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Authors
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روشن مهر هوشنگ ,رستمی مراد ,کامیاری ناصر
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Abstract
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زمینه و اهداف:DNA متیل ترانسفراز3A برای تنظیم بیان ژن ضروری است و جهش ها در ژن DNMT3A در بسیاری از سرطان های خون گزارش شده است.جهش های DNMT3A در طول پیشرفت سرطان موجود است و سبب پیش آگهی منفی در بسیاری از سرطان ها می شود.بنابراین،این ژن می تواند هدفی برای درمان های جدید باشد.این مطالعه با هدف بررسی توزیع جهش های DNMT3A در بیماران لوسمی حاد ایرانی انجام شد.مواد و روش ها:در این مطالعه نمونه های 45 بیمار لوسمی حاد de novo ، شامل 23 بیمار AML و 22 بیمار ALL از فروردین 1396 تا اسفند 1396 جهت شیوع جهش های DNMT3A با PCR و سکانس مستقیم بررسی شد.نتایج:در کل 2(9.1%) مورد AML و یک(4.34%) مورد ALL دارای جهش R882H بودند .22.7% و 21.7% بیماران AML وALL به ترتیب دارای پلی مورفیسم rs368516543 بودند.جهش های DNMT3A بطور قابل توجهی با سن بالاتر در بیماران AML مرتبط بود.نتیجه گیری:این یافته ها پیشنهاد می کند که جهش های DNMT3A احتمالا بیومارکری جدید در بررسی اولیه و درمان لوسمی حاد است،هرچند مطالعات بیشتر نیاز است.
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Keywords
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