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Ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable-polymer everolimus-eluting stent for percutaneous coronary revascularization: 2-year results of the BIOSCIENCE trial
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نویسنده
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zbinden r. ,piccolo r. ,heg d. ,roffi m. ,kurz d.j. ,muller o. ,vuilliomenet a. ,cook s. ,weilenmann d. ,kaiser c. ,jamshidi p. ,franzone a. ,eberli f. ,jcuni p. ,windecker s. ,pilgrim t.
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منبع
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journal of the american heart association - 2016 - دوره : 5 - شماره : 3
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چکیده
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Background-no data are available on the long-term performance of ultrathin strut biodegradable polymer sirolimus-eluting stents (bp-ses). we reported 2-year clinical outcomes of the bioscience (ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable polymer everolimus-eluting stent for percutaneous coronary revascularisation) trial,which compared bp-ses with durable-polymer everolimus-eluting stents (dp-ees) in patients undergoing percutaneous coronary intervention. methods and results-a total of 2119 patients with minimal exclusion criteria were assigned to treatment with bp-ses (n=1063) or dp-ees (n=1056). follow-up at 2 years was available for 2048 patients (97%). the primary end point was targetlesion failure,a composite of cardiac death,target-vessel myocardial infarction,or clinically indicated target-lesion revascularization. at 2 years,target-lesion failure occurred in 107 patients (10.5%) in the bp-ses arm and 107 patients (10.4%) in the dp-ees arm (risk ratio [rr] 1.00,95% ci 0.77-1.31,p=0.979). there were no significant differences between bpses and dp-ees with respect to cardiac death (rr 1.01,95% ci 0.62-1.63,p=0.984),target-vessel myocardial infarction (rr 0.91,95% ci 0.60-1.39,p=0.669),target-lesion revascularization (rr 1.17,95% ci 0.81-1.71,p=0.403),and definite stent thrombosis (rr 1.38,95% ci 0.56-3.44,p=0.485). there were 2 cases (0.2%) of definite very late stent thrombosis in the bpses arm and 4 cases (0.4%) in the dp-ees arm (p=0.423). in the prespecified subgroup of patients with st-segment elevation myocardial infarction,bp-ses was associated with a lower risk of target-lesion failure compared with dp-ees (rr 0.48,95% ci 0.23-0.99,p=0.043,pinteraction=0.026). conclusions-comparable safety and efficacy profiles of bp-ses and dp-ees were maintained throughout 2 years of follow-up. © 2016 the authors.
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کلیدواژه
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Biodegradable polymer; Drug-eluting stent; Everolimus-eluting stent; Percutaneous coronary intervention; Sirolimus-eluting stent
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آدرس
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department of cardiology,triemlispital,zurich, Switzerland, department of cardiology,swiss cardiovascular center,university hospital,bern, Switzerland, institute of social and preventive medicine and clinical trials unit,bern university hospital,bern, Switzerland, division of cardiology,university hospital,geneva, Switzerland, department of cardiology,triemlispital,zurich, Switzerland, department of cardiology,university hospital,lausanne, Switzerland, department of cardiology,kantonsspital,aarau, Switzerland, department of cardiology,university hospital,fribourg, Switzerland, department of cardiology,kantonsspital,st. gallen, Switzerland, department of cardiology,university hospital,basel, Switzerland, department of cardiology,kantonsspital,luzern, Switzerland, department of cardiology,swiss cardiovascular center,university hospital,bern, Switzerland, department of cardiology,triemlispital,zurich, Switzerland, applied health research centre (ahrc),li ka shing knowledge institute of st. michael's hospital,toronto,canada,department of medicine,university of toronto,toronto, Canada, department of cardiology,swiss cardiovascular center,university hospital,bern, Switzerland, department of cardiology,swiss cardiovascular center,university hospital,bern, Switzerland
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Authors
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