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   years of able life in older persons-the role of cardiovascular imaging and biomarkers: the cardiovascular health study  
   
نویسنده alshawabkeh l.i. ,yee l.m. ,gardin j.m. ,gottdiener j.s. ,odden m.c. ,bartz t.m. ,arnold a.m. ,mukamal k.j. ,wallace r.b.
منبع journal of the american heart association - 2015 - دوره : 4 - شماره : 4
چکیده    Background-as the u.s. population grows older,there is greater need to examine physical independence. previous studies have assessed risk factors in relation to either disability or mortality,but an outcome that combines both is still needed. methods and results--the cardiovascular health study is a population-based,prospective study where participants underwent baseline echocardiogram,measurement of carotid intima-media thickness (imt),and various biomarkers,then followed for up to 18 years. years of able life (yal) constituted the number of years the participant was able to perform all activities of daily living. linear regression was used to model the relationship between selected measures and outcomes,adjusted for confounding variables. among 4902 participants,mean age was 72.65.4 years,median yal for males was 8.8 (interquartile range [iqr],4.3 to 13.8) and 10.3 (iqr,5.8 to 15.8) for females. reductions in yal in the fully adjusted model for females and males,respectively,were: -1.34 (95% confidence interval [ci],-2.18,-0.49) and -1.41 (95% ci,-2.03,-0.8) for abnormal left ventricular (lv) ejection fraction,-0.5 (95% ci,-0.78,-0.22) and -0.62 (95% ci,-0.87,-0.36) per sd increase in lv mass,-0.5 (95% ci,-0.7,-0.29) and -0.79 (95% ci,-0.99,-0.58) for imt,-0.5 (95% ci,-0.64,-0.37) and -0.79 (95% ci,-0.94,-0.65) for n-terminal pro-brain natriuretic peptide,-1.08 (95% ci,-1.34,-0.83) and -0.73 (95% ci,-0.97,-0.5) for high-sensitivity troponin-t,and -0.26 (95% ci,-0.42,-0.09) and -0.23 (95% ci,-0.41,-0.05) for procollagen-iii n-terminal propeptide. most tested variables remained significant even after adjusting for incident cardiovascular (cv) disease. conclusions--in this population-based cohort,variables obtained by cv imaging and biomarkers of inflammation,coagulation,atherosclerosis,myocardial injury and stress,and cardiac collagen turnover were associated with yal,an important outcome that integrates physical ability and longevity in older persons. © 2015 the authors.
کلیدواژه Activities of daily living; Aging; Biomarkers; Imaging
آدرس division of cardiovascular medicine,university of iowa,iowa city,ia,united states,carver college of medicine and the college of public health,university of iowa,iowa city,ia, United States, department of biostatistics,university of washington,seattle,wa, United States, department of medicine,hackensack university medical center,hackensack,nj, United States, division of cardiovascular medicine,department of medicine,university of maryland school of medicine,baltimore,md, United States, school of biological and population health sciences,college of public health and human sciences,oregon state university,corvallis,or, United States, department of biostatistics,university of washington,seattle,wa, United States, department of biostatistics,university of washington,seattle,wa, United States, division of cardiovascular medicine,university of iowa,iowa city,ia,united states,divisions of general medicine and primary care,beth israel deaconess medical center and harvard medical school,boston,ma, United States, department of internal medicine,university of iowa,iowa city,ia,united states,carver college of medicine and the college of public health,university of iowa,iowa city,ia, United States
 
     
   
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