Predictive utility of the changes in matrix metalloproteinase-2 in the early phase for left ventricular reverse remodeling after an acute myocardial infarction

Background: the relationship between the serum levels of matrix metalloproteinase (mmp) and tissue inhibitors of mmp (timp) and left ventricular (lv) reverse remodeling (lv-rr) after an acute myocardial infarction (ami) has not been sufficiently examined.methods and results: in 25 patients with successful reperfusion after an ami and 15 normal control subjects,the serum mmp-2 and timp-2 levels were measured on days 1,2,3,and 7 and at 1 and 6 months after the ami onset. lv-rr was defined as a >15% decrease in the lv end-systolic volume index at 6 months after the ami. the mmp-2 level on day 1 and timp-2 levels throughout the study period were comparable between the patients with and without lv-rr. the mmp-2 on day 7 (p<0.05) and the changes in the mmp-2 from day 1 to day 7 (∆mmp-2; p<0.01) were lower in patients with than in those without lv-rr. the ∆mmp-2 was strongly correlated with the changes in the lv volume and ejection fraction from 1 month to 6 months after the ami. the ∆mmp-2 value of <-158.5 ng/ml predicted lv-rr with a high accuracy (91.7% sensitivity and 76.9% specificity; area under the curve=0.82).conclusions: changes in mmp-2 are associated with lv-rr after an ami. the δmmp-2 might be a useful predictor of subsequent lv-rr. © 2015 the authors. published on behalf of the american heart association,inc.,by wiley blackwell.