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Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success
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نویسنده
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choi e.-k. ,park j.h. ,lee j.-y. ,nam c.m. ,hwang m.k. ,uhm j.-s. ,joung b. ,ko y.-g. ,lee m.-h. ,lubitz s.a. ,ellinor p.t. ,pak h.-n.
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منبع
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journal of the american heart association - 2015 - دوره : 4 - شماره : 8 - صفحه:e002046
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چکیده
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Background: genomewide association studies have identified several loci associated with atrial fibrillation (af) and have been reportedly associated with response to catheter ablation for af in patients of european ancestry; however,associations between top susceptibility loci and af recurrence after ablation have not been examined in asian populations. we examined whether the top single nucleotide polymorphisms (snps) at chromosomes 4q25 (pitx2),16q22 (zfhx3),and 1q21 (kcnn3) were associated with af in a korean population and whether these snps were associated with clinical outcomes after catheter ablation for af.methods and results: we determined the association between 4 snps and af in 1068 af patients who underwent catheter ablation (74.6% male,aged 57.5±10.9 years,67.9% paroxysmal af) and 1068 age- and sex-matched controls. the snps at the pitx2 and zfhx3 loci,but not the kcnn3 locus,were significantly associated with af (pitx2/rs6843082_g: odds ratio 3.41,95% ci 2.55 to 4.55,p=1.32×10(-16); pitx2/rs2200733_t: odds ratio 2.05,95% ci 1.66 to 2.53,p=2.20×10(-11); zfhx3/rs2106261_a: odds ratio 2.33,95% ci 1.87 to 2.91,p=3.75×10(-14); kcnn3/rs13376333_t: odds ratio 1.74,95% ci 0.93 to 3.25,p=0.085). among those patients who underwent catheter ablation for af,none of the top af-associated snps were associated with long-term clinical recurrence of af after catheter ablation.conclusions: snps at the pitx2 and zfhx3 loci were strongly associated with af in korean patients. in contrast to prior reports,none of the 4 top af-susceptibility snps predicted clinical recurrence after catheter ablation. © 2015 the authors. published on behalf of the american heart association,inc.,by wiley blackwell.
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کلیدواژه
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atrial fibrillation; catheter ablation; genetic polymorphism; phenotype; recurrence
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آدرس
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department of internal medicine,seoul national university hospital,seoul, Korea (E.K.C.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.), cardiac arrhythmia service and cardiovascular research center,massachusetts general hospital,boston,ma (s.a.l.,p.t.e.) program in medical and population genetics,the broad institute of harvard and mit,cambridge,ma (s.a.l., P.T.E.), cardiac arrhythmia service and cardiovascular research center,massachusetts general hospital,boston,ma (s.a.l.,p.t.e.) program in medical and population genetics,the broad institute of harvard and mit,cambridge,ma (s.a.l., P.T.E.), cardiovascular genome center,yonsei university health system,seoul,korea (j.h.p.,j.y.l.,c.m.n.,m.k.h.,j.s.u.,b.j.,y.g.k.,m.h.l., H.N.P.)
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Authors
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