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   Aldosterone predicts cardiovascular,renal,and metabolic disease in the general community: A 4-year follow-up  
   
نویسنده buglioni a. ,cannone v. ,sangaralingham s.j. ,heublein d.m. ,scott c.g. ,bailey k.r. ,rodeheffer r.j. ,sarzani r. ,burnett j.c.
منبع journal of the american heart association - 2015 - دوره : 4 - شماره : 12
چکیده    Background-we recently reported that normal aldosterone levels are associated with cardiovascular,renal,and metabolic disease in a sample of the us general community (visit 1). for the current analyses we used the same cohort in a new 4-year follow-up study (visit 2). methods and results-we measured aldosterone at visit 1 and analyzed its predictive role for new diseases at visit 2 (n=1140). we measured aldosterone at visit 2 and investigated its associations with disease at visit 2 (n=1368). we analyzed aldosterone continuously and we also dichotomized the variable as whether subjects were in the third tertile versus second and first tertiles. as continuous variable at visit 1,aldosterone predicted new onset hypertension (htn) (or=1.36,ci=1.13-1.63,p=0.001),central obesity (or=1.36,ci=1.07-1.73,p=0.011),and use of lipid-lowering drugs (or=1.25,ci=1.05-1.48,p=0.012) at visit 2,after adjustment for age,sex,and body mass index. when in the third tertile (8.5-88.6 ng/dl),aldosterone predicted type 2 diabetes (t2dm,or=1.96,ci=1.03-3.70,p=0.039). at visit 2,aldosterone remained associated with htn,obesity,and chronic kidney disease (ckd),as reported for visit 1. however,aldosterone was not associated with heart failure (hf) at visit 1 and 2,nor was aldosterone a predictor of hf between visits. conclusions-aldosterone predicts new htn,central obesity,t2dm,and use of lipid-lowering drugs in the general community and remains associated with htn,obesity,and ckd over 4 years. aldosterone is not associated nor predicts hf. further studies are warranted to evaluate aldosterone as therapeutic target in the general community. © 2015 the authors.
کلیدواژه Aldosterone; Diabetes mellitus; General community; Heart failure; Obesity
آدرس cardiorenal research laboratory,college of medicine mayo clinic,rochester,mn,united states,division of cardiovascular diseases,departments of medicine,college of medicine mayo clinic,rochester,mn, United States, cardiorenal research laboratory,college of medicine mayo clinic,rochester,mn,united states,division of cardiovascular diseases,departments of medicine,college of medicine mayo clinic,rochester,mn, United States, cardiorenal research laboratory,college of medicine mayo clinic,rochester,mn,united states,division of cardiovascular diseases,departments of medicine,college of medicine mayo clinic,rochester,mn, United States, cardiorenal research laboratory,college of medicine mayo clinic,rochester,mn,united states,division of cardiovascular diseases,departments of medicine,college of medicine mayo clinic,rochester,mn, United States, health sciences research,college of medicine mayo clinic,rochester,mn, United States, health sciences research,college of medicine mayo clinic,rochester,mn, United States, division of cardiovascular diseases,departments of medicine,college of medicine mayo clinic,rochester,mn, United States, internal medicine and geriatrics and hypertension excellence centre,european society of hypertension,university politecnica delle marche,department of clinical and molecular sciences,ancona,italy,italian national research centre on aging u. sestilli,irccs-inrca,ancona, Italy, jr.,cardiorenal research laboratory,college of medicine mayo clinic,rochester,mn,united states,division of cardiovascular diseases,departments of medicine,college of medicine mayo clinic,rochester,mn, United States
 
     
   
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