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Dietary α-linolenic acid,marine ω-3 fatty acids,and mortality in a population with high fish consumption: Findings from the PREvención con DIeta MEDiterránea (PREDIMED) Study
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نویسنده
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sala-vila a. ,guasch-ferré m. ,hu f.b. ,sánchez-tainta a. ,bulló m. ,serra-mir m. ,lópez-sabater c. ,sorlí j.v. ,arós f. ,fiol m. ,muñoz m.a. ,serra-majem l. ,alfredo martínez j. ,corella d. ,fitó m. ,salas-salvadó j. ,martínez-gonzález m.a. ,estruch r. ,ros e. ,pérez-heras a. ,viñas c. ,casas r. ,de santamaría l. ,romero s. ,sacanella e. ,chiva g. ,valderas p. ,arranz s. ,baena j.m. ,garcía m. ,oller m. ,amat j. ,duaso i. ,garcía y. ,iglesias c. ,simón c. ,quinzavos l. ,parra l. ,liroz m. ,benavent j. ,clos j. ,pla i. ,amorós m. ,bonet m.t. ,martin m.t. ,sánchez m.s. ,altirriba j. ,manzano e. ,altés a. ,cofán m. ,valls-pedret c. ,doménech m. ,gilabert r. ,bargalló n. ,gonzález r. ,molina c. ,márquez f. ,babio n. ,sorli m. ,garcía roselló j. ,diaz-lópez a. ,martin f. ,tort r. ,isach a. ,costa b. ,cabré j.j. ,fernández-ballart j. ,ibarrola-jurado n. ,alegret c. ,martínez p. ,millán s. ,piñol j.l. ,basora t. ,hernández j.m. ,toledo e. ,buil-cosiales p. ,ruiz-canela m. ,sanjulián b. ,díez-espino j. ,extremera-urabayen v. ,garcía-arellano a. ,zazpe i. ,basterra-gortari f.j. ,goñi e. ,razquin c. ,serrano-martínez m. ,bes-rastrollo m. ,gea a. ,martínez-lapiscina e.h. ,nuñez-córdoba j.m. ,arroyo-azpa c. ,garcía-pérez l. ,villanueva-tellería j. ,cortés-ugalde f. ,sagredo-arce t. ,de la noceda-montoy m.d.g. ,vigata-lópez m.d. ,arceiz-campo m.t. ,urtasun-samper a. ,gueto-rubio m.v. ,churio-beraza b. ,lamuela-raventós r.m. ,castellote-bargallo a.i. ,medina-remón a. ,tresserra-rimbau a. ,carrasco p. ,ortega-azorín c. ,asensio e.m. ,osma r. ,barragán r. ,francés f. ,guillén m. ,gonzález j.i. ,saiz c. ,portolés o. ,giménez f.j. ,coltell o. ,guillem-saiz p. ,quiles l. ,pascual v. ,riera c. ,pages m.a. ,godoy d. ,carratalá-calvo a. ,martín-rillo m.j. ,llopis-osorio e. ,ruiz-baixauli j. ,bertolín-muñoz a. ,salaverría i. ,del hierro t. ,algorta j. ,francisco s. ,alonso a. ,san vicente j. ,sanz e. ,felipe i. ,alonso gómez a. ,loma-osorio a. ,garcía-valdueza m. ,moñino m. ,proenza a. ,prieto r. ,frontera g. ,ginard m. ,fiol f. ,jover a. ,garcía j. ,covas m.i. ,tello s. ,vila j. ,schröder h. ,de la torre r. ,muñoz-aguayo d. ,elosúa r. ,marrugat j. ,ferrer m. ,álvarez-pérez j. ,díaz benítez e. ,bautista-castaño i. ,maldonado-díaz i. ,sánchez-villegas a. ,castro i. ,henríquez p. ,ruano c. ,ortiz a.p. ,sarmiendo de la fe f. ,simón-garcía c. ,falcón-sanabria i. ,macías-gutiérrez b. ,santana-santana a.j. ,gomez-gracia e. ,fernández-crehuet j. ,benítez pont r. ,bianchi alba m. ,wärnberg j. ,gómez-huelgas r. ,martínez-gonzález j. ,velasco garcía v. ,de diego salas j. ,baca osorio a. ,gil zarzosa j. ,sánchez luque j.j. ,vargas lópez e. ,ruiz-gutierrez v. ,jurado ruiz e. ,montero romero e. ,garcía garcía m. ,lapetra j. ,leal m. ,martínez e. ,santos j.m. ,ortega-calvo m. ,román p. ,josé garcía f. ,iglesias p. ,corchado y. ,mayoral e. ,lama c. ,pintó x. ,de la cruz e. ,galera a. ,soler y. ,trias f. ,sarasa i. ,padres e. ,figueras r. ,solanich x. ,pujol r. ,corbella e. ,cabezas c. ,vinyoles e. ,rovira m.a. ,garcía l. ,flores g. ,verdú j.m. ,baby p. ,ramos a. ,mengual l. ,roura p. ,yuste m.c. ,guarner a. ,rovira a. ,santamaría m.i. ,mata m. ,de juan c. ,brau a. ,marti a. ,mitjavila m.t. ,portillo m.p. ,sáez g. ,tur j.
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منبع
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journal of the american heart association - 2016 - دوره : 5 - شماره : 1
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چکیده
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Background-epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ala),a plant-derived ω-3 fatty acid. it is unclear whether ala is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. in persons at high cardiovascular risk from spain,a country in which fish consumption is customarily high,we investigated whether meeting the international society for the study of fatty acids and lipids recommendation for dietary ala (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. we also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day). methods and results-we longitudinally evaluated 7202 participants in the prevención con dieta mediterránea (predimed) trial. multivariable-adjusted cox regressionmodels were fitted to estimate hazard ratios. ala intake correlated towalnut consumption (r=0.94). during a 5.9-y follow-up,431 deaths occurred (104 cardiovascular disease,55 coronary heart disease,32 sudden cardiac death,25 stroke). the hazard ratios formeeting alarecommendation (n=1615,22.4%) were 0.72 (95% ci 0.56-0.92) for all-causemortality and 0.95 (95% ci 0.58-1.57) for fatal cardiovascular disease. the hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n=5452,75.7%) were 0.84 (95% ci 0.67-1.05) for all-causemortality,0.61 (95% ci 0.39-0.96) for fatal cardiovascular disease,0.54 (95% ci 0.29-0.99) for fatal coronary heart disease,and 0.49 (95% ci 0.22-1.01) for sudden cardiac death. the highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% ci 0.45-0.87]). conclusions-in participants without prior cardiovascular disease and high fish consumption,dietary ala,supplied mainly by walnuts and olive oil,relates inversely to all-cause mortality,whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids. © 2016 the authors.
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کلیدواژه
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Fatty acid; Nutrition; Sudden cardiac death
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آدرس
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ciber fisiopatología de la obesidad y nutrición (ciberobn),instituto de salud carlos iii (isciii),madrid,spain,lipid clinic,department of endocrinology and nutrition,institut d'investigacions biomèdiques august pi i sunyer,hospital clinic,barcelona, Spain, human nutrition unit,biochemistry biotechnology department,faculty of medicine and health sciences,universitat rovira i virgili,hospital universitari de sant joan de reus,iispv,reus, Spain, departments of nutrition and epidemiology,harvard school of public health,boston,ma, United States, department of preventive medicine and public health,university of navarra,pamplona, Spain, human nutrition unit,biochemistry biotechnology department,faculty of medicine and health sciences,universitat rovira i virgili,hospital universitari de sant joan de reus,iispv,reus, Spain, lipid clinic,department of endocrinology and nutrition,institut d'investigacions biomèdiques august pi i sunyer,hospital clinic,barcelona, Spain, department of nutrition and food science,school of pharmacy,xarta,insa,university of barcelona,pamplona, Spain, department of preventive medicine,university of valencia, Spain, department of cardiology,university hospital of alava,vitoria, Spain, institute of health sciences,instituto de investigación sanitaria de palma,palma de mallorca, Spain, cardiovascular risk and nutrition research group,institut hospital del mar d'investigacions mèdiques (imim),barcelona biomedical research park,barcelona, Spain, research institute of biomedical and health sciences,university of las palmas de gran canaria,las palmas, Spain, department of nutrition and food sciences,physiology and toxicology,university of navarra,pamplona, Spain, department of preventive medicine,university of valencia, Spain, cardiovascular risk and nutrition research group,institut hospital del mar d'investigacions mèdiques (imim),barcelona biomedical research park,barcelona, Spain, human nutrition unit,biochemistry biotechnology department,faculty of medicine and health sciences,universitat rovira i virgili,hospital universitari de sant joan de reus,iispv,reus, Spain, department of preventive medicine and public health,university of navarra,pamplona, Spain, department of internal medicine,institut d'investigacions biomèdiques august pi i sunyer,hospital clinic,barcelona, Spain, lipid clinic,department of endocrinology and nutrition,institut d'investigacions biomèdiques august pi i sunyer,hospital clinic,barcelona, Spain, hospital clínic,institut d'investigacions biomèdiques august pi i sunyer,barcelona, Spain, hospital clínic,institut d'investigacions biomèdiques august pi i sunyer,barcelona, Spain, hospital clínic,institut d'investigacions biomèdiques august pi i sunyer,barcelona, Spain, hospital clínic,institut d'investigacions biomèdiques august pi i sunyer,barcelona, Spain, hospital clínic,institut d'investigacions biomèdiques august pi i sunyer,barcelona, Spain, hospital clínic,institut d'investigacions biomèdiques august pi i 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